UCHealth was awarded a Proof-Of-Concept grant from the the Colorado Office of Economic Development and International Trade (OEDIT), and selected RxRevu as its partner to co-develop technology that operationalizes evidence-based best practices in Emergency Medicine. Since this technology was launched at UCHealth in October of 2016, there has been marked improvement in the prescribing of first-line antibiotics and marked reduction in non-recommended antibiotics. These recommendations are condition specific and based on UCHealth's antibiogram in an effort to reduce antibiotic resistance and improve outcomes.

The Office of the National Coordinator of Heath IT (ONC) issued a High Impact Pilots competition which 4 institutions nationwide, including RxRevu, won. This grant funded the development of a point-of-care price transparency software tool, directly embedded in the Electronic Health Record at Banner Health. This tool enables health care providers to search for a medication and see: what the patient will pay for that medication, where the patient is at in their deductible, and if they are adherent to that class of medication, all in an actionable order screen. This project also uses the emerging national standard called Fast-Healthcare Interoperability Resources to deliver specific features in the tool.

RxRevu was awarded an Early Stage Capital and Retention grant from the Colorado Office of Economic Development and International Trade (OEDIT). This grant, in collaboration with UCHealth, funded a project to automatically detect when high-risk heart failure (HF) patients are not prescribed evidence-based medications, and gives healthcare providers a non-interruptive method to ensure their HF patients are taking medications proven to improve quality of life, prevent death, reduce hospitalizations, and lower healthcare costs.

Prescribing medications for mental health remains a challenge. In an effort to use unbiased biological data to improve prescribing in mental health, RxRevu partnered with the Mental Health Center of Denver and was awarded a Phase I Small Business Innovation Research grant from the National Institute of Mental Health (NIMH) to develop a software tool that converts a patient's pharmacogenetic test results into a digestible/machine readable format, and incorporates mental health provider preferences into a user interface that serves as a one-stop view in the Electronic Health Record for mental health providers to make the most up-to-date and informed decisions about what medications they select for their patients.

RxRevu and Vanderbilt University Medical Center are collaborating to build Safety Through E-Prescribing Tools (STEPSTools), a knowledge platform designed for determining potential formulations to reach the target dosage, within the rounding tolerance specific to each pediatric medication. These formulations will then be scored and prioritized in the user interface, based on safety and efficacy. The number of tablets/administrations, volume and proximity to target dose will be taken into consideration when scoring the options. A narrative will be generated to provide documentation for the scoring and recommendations. This project is funded by a Phase I SBIR through the National Institute of Child Health and Human Development (NICHD).

Many aspects of antimicrobial stewardship require "boots on the ground" methods or annual updates to large instruction manuals to disseminate new evidence. RxRevu and Children's Hospital Colorado (CHCO) are collaborating to bring CHCO's pediatric antimicrobial stewardship guidelines directly to the point of prescribing, in the provider's electronic health record (EHR) workflow. Meaning institutional standards for first-line medications and appropriate dosages per infectious condition will be surfaced in an actionable manner directly in the EHR.